Health Condition 1: K721- Chronic hepatic failure
Conditions
Interventions
Intervention1: Group A: Group A will receive drug packets containing 2.5 gm sodium benzoate and 5 gm powdered table sugar for 5 days.Since the dosage of Sodium Benzoate is Stat 250mg/Kg and then 250mg
Sponsors
Department of Pediatric Hepatology
Eligibility
Inclusion criteria
Inclusion criteria: Infants, children and adolescents under 18 years of age with decompensated Chronic liver disease with hyperammonemia < 400 mcgm and /dl.
Exclusion criteria
Exclusion criteria: 1. Patients who have received sodium benzoate within 1 week prior to evaluation. 2. Baseline serum sodium above 155 mEq/L 3. Patients with Grade 3 ascites as per IAC classification. 4. Patients who did not give a written informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in the blood ammonia levels at 5 days of starting therapy.Timepoint: Day 5 | — |
Secondary
| Measure | Time frame |
|---|---|
| o Change in grade of HE from day 0 to day 5 for overt HE. o Proportion of children with worsening ascites, hypernatremia and metabolic acidosis. o Duration of hospital stay. o Short term survival (28 days and 90 days) with native liverTimepoint: Day 28 and Day 90;SurvivalTimepoint: day 90 | — |
Countries
India
Contacts
Public ContactSnehavardhan Pandey
Institute of Liver and Biliary Sciences, New Delhi
Outcome results
None listed