Health Condition 1: null- Acute moderate exacerbation of bronchial asthma
Conditions
Interventions
Intervention1: oral prednisolone 1mg/kg single dose For 3 Days: single dose of oral prednisolone 1mg/kg For 3 Days
Control Intervention1: comparator agent is oral prednisolone single dose 2 mg/kg
For
Sponsors
Jawaharlal Institute Of Postgraduate Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria: Children aged 1-5 years with more than 2 episodes of physician diagnosed wheeze and EITHER i) a physician documented improvement in signs with short acting beta agonist (SABA) therapy with or without oral corticosteroids OR ii) Convincing parental report of symptomatic response to a three month trial of medium dose inhaled corticosteroids with or without SABA AND with moderate exacerbation assessed with PRAM score (score >=4 to
Exclusion criteria
Exclusion criteria: . Exclusion criteria Clinical evidence of other known chronic respiratory conditions - both suppurative and non suppurative (bronchiectasis, cystic fibrosis, congenital airway anomalies) History suggestive of recurrent aspiration in the past Clinical suspicion of pneumonia Children with congenital heart disease Children with failure to thrive Children already on oral prednisolone, monteleukast or azithromycin therapy Children with poor oral intake, drowsiness or vomiting Children with features suggestive of life threatening asthma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion Of Children With PRAM score less than 4 at 4 hours after intervention Timepoint: PRAM score Hourly for the first 4 hours followed by 8 , 24, 48 and 72 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of children requiring escalation of treatment , Proportion requiring readmission within 7 days Side effect profile between the two groups Timepoint: 7 days | — |
Countries
India
Contacts
Public ContactDr Venkatesh Chandrasekaran
JAWAHARLAL INSTITUTE OF PG MEDICAL EDUCATION AND RESEARCH
Outcome results
None listed