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Comparison of medicines to prevent nausea and vomiting after surgery to remove gall bladder through a very small incision with gas insufflation of abdomen.

A comparison of intravenous ondansetron and palonosetron in preventing post-operative nausea and vomiting after laparoscopic cholecystectomy: a randomised double blind study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/08/009295
Enrollment
100
Registered
2017-08-08
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients undergoing laparoscopic cholecystectomy

Interventions

Intervention1: palonosetron hydrochloride injection: Patients received 75ï?­g (1.5 ml) injection palonosetron diluted up to 4 ml with normal saline given slowly intravenously over 10 seconds,3 minute

Sponsors

Deen Dayal Upadhyay Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients posted for laparoscopic cholecysectomy

Exclusion criteria

Exclusion criteria: 1. Patients with previous history of PONV or motion sickness. 2. Menstruating, pregnant or lactating women. 3. Patients receiving opioids, steroids, psychoactive drugs or antiemetic drugs within 24 hours before anaesthesia. 4. Patients who received cancer chemotherapy within 4 weeks or emetogenic radiotherapy within 8 weeks. 5. Patients who were smokers, obese, had diabetes, psychiatric diseases or gastrointestinal tract disease. 6. Patients posted for an emergency surgery.

Design outcomes

Primary

MeasureTime frame
Incidence of postoperative nausea and vomiting in both the groups were observedTimepoint: 0-2 hours, 2-6 hours, 6-24 hours, 24-48 hours after completion of surgery—

Secondary

MeasureTime frame
Comparison of side-effects of the two study drugsTimepoint: Till 48 hours after completion of surgery—

Countries

India

Contacts

Public ContactDr Sumita

Department of Anaesthesiology & Critical Care, DDU Hospital, Govt. of Delhi

ajayannu@gmail.com9718990114

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026