A clinical trial to study fluid therapy in very sick patients with metabolic alterations comparing ringer lactate and acetate solution

EFFECT OF FLUID RESUSCITATION WITH RINGERâ??S LACTATE VS ACETATE SOLUTION ON EXTENT OF CORRECTION OF METABOLIC ACIDOSIS IN CRITICALLY ILL PATIENTS - RLAcMA

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/08/009261

Enrollment

Registered

2017-08-04

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Critically ill patients having metabolic acidosis

Interventions

Intervention1: Acetate Solution: Acetate solution 30 ml/kg over 2 hours Control Intervention1: Ringer Lactate: Ringer lactate 30 ml/Kg over 2 hours

Eligibility

Inclusion criteria

Inclusion criteria: All adult patients admitted to Main ICU with metabolic acidosis i.e. pH less than 7.29 and standard HCO3- less than19mmol/l).

Exclusion criteria

Exclusion criteria: Patients with contraindication to large volume fluid resuscitation for example: anuria secondary to renal failure, left ventricular failure.

Design outcomes

Primary

Measure	Time frame
Primary outcome of the study is the time to correction of pH till 7.30 in critically ill patients with metabolic acidosis.Timepoint: 2 hours	—

Secondary

Measure	Time frame
Secondary outcome of the study will be to assess change in pH, lactate level, bicarbonate and base deficit during the period of resuscitation (that is, the time to correction of pH till 7.30), volume of IV fluid used for correction and also the total cost of IV fluid used for resuscitation.Timepoint: 2 hours	—

Countries

India

Contacts

Public ContactDr Neha Rawat

PGIMER Chandigarh

neerunalin@yahoo.com7087009005

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026