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To see whether measuring blood pressure change correlates with measuring speed & time of flowing of major blood vessels in pts undergoing major surgeries under generl anesthesia on artificial breathing machine that can help in identifying which pts will get benefited frm giving fluids.

To determine whether Pulse Pressure Variation correlates with Brachial artery velocity time integral and Carotid velocity time integral in predicting fluid responsiveness in patients undergoing major surgeries under general anesthesia with controlled mechanical ventilation. - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2017/08/009243
Enrollment
20
Registered
2017-08-03
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Adult patients undergoing elective surgeries having major blood loss or fluid shifts requiring cardiac output monitoring under general anaesthesia

Interventions

Intervention1: Nil: Nil Control Intervention1: Nil: Nil

Sponsors

Tata Memorial Centre
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Adult patients (Age > 18 yrs ) 2.Elective surgeries cases having major blood loss or fluid shifts requiring cardiac output monitoring under general anaesthesia 3.Receiving lung ventilation 8 ml/kg PBW using Volume Assist Control mode. 4.With invasive arterial blood pressure monitoring and cardiac output monitoring using Flotrac EV1000

Exclusion criteria

Exclusion criteria: 1.Age under 18 years 2.Patient in whom brachial artery could not be identified with certainty viz above elbow amputated patients and patient with known PVD. 3.absence of sinusrhythm, 4.presence of a ventricular assist device 5.Carotid artery stenosis( common carotid artery stenosis greater than 50 %(systolic peak velocity >182 cm/s and/or diastolic velocity >30 cm/s by Doppler ultrasound)-as assessed by clinician from critical care with previous formal training in critical care ultrasound 6.contraindication to the prespecified ventilatory parameters (a period of passive ventilation at tidal volume [Vt] 8 mL/kg of predicted body weight 7.Known heart failure and LVEF 8.Valvular heart disease 9.Aortic insufficiency 10.Air leakage through chest drains 11.spontaneous respiratory efforts

Design outcomes

Primary

MeasureTime frame
To determine whether brachial artery velocity time integral and carotid artery velocity time integral could substitute as an accurate, noninvasive surrogate for Pulse Pressure Variation in predicting fluid responsiveness in patients undergoing major surgeries with controlled mechanical ventilationTimepoint: before and after fluid bolus—

Secondary

MeasureTime frame
NilTimepoint: Nil—

Countries

India

Contacts

Public ContactDr Pravin Dhakne

Tata Memorial Hospital,Parel,Mumbai

jmalini2007@rediffmail.com91-9987226657

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 19, 2026