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To decrease the response of intubation using either esmolol or enalaprilat in controlled hypertensive patients

To compare the efficacy of pretreatment with intravenous enalaprilat or esmolol, in attenuating the pressor response to intubation in controlled hypertensive patients undergoing surgeries under general anesthesia requiring tracheal intubation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/08/009230
Enrollment
90
Registered
2017-08-02
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients with controlled hypertension, scheduled for surgery under general anaesthesia requiring tracheal intubation will be recruited

Interventions

Intervention1: Group II: injection esmolol pretreatment Group III: injection enalaprilat pretreatment: Group II: Patients will be started with IV infusion of 50 ml normal saline 15 minutes before indu

Sponsors

DRPGMCKangra at Tanda
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: The patients will be surgical candidates, either gender,aged 40-60 yrs weighing 40-70 kgs and controlled hypertensive patient,belonging to ASA II, scheduled for surgery under general anaesthesia requiring tracheal intubation

Exclusion criteria

Exclusion criteria: 1. Patients having recent myocardial infarction (less than 6 months duration), partial and complete heart block, bradycardia. 2. Patients having chronic obstructive lung disease, asthma 3. Patients having marked systolic and diastolic dysfunction based upon electrocardiographic or echocardiographic studies as indicated. 4. Severe renal or hepatic dysfunction 5. Morbidly obese patients , pregnant females 6. Bilateral renal artery stenosis 7. Hypersensitivity to ACE inhibitors 8. Patients with anticipated difficult intubation 9. Diabetic patients 10. Patients already on tablet enalaprilat or β blocker drugs in the preoperative period.

Design outcomes

Primary

MeasureTime frame
Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) will be recorded baseline, after study drug administration, after induction and 1, 3, 5, 10, and 15 min after orotracheal intubation.Timepoint: Time Points Induction Intubation 1 min after intubation 3 min after intubation 5 min after intubation 10 min after intubation 15 min after intubation—

Secondary

MeasureTime frame
Rate Pressure Product on induction, intubation and incidence of adverse effetcs if anyTimepoint: induction, intubation 1 min after intubation 3 minutes after intubation 5 min after intubation 10 min after intubation 15 min after intubation 2) incidence of side effetcs if any over a aperiod of 24 h—

Countries

India

Contacts

Public ContactDr Sudarshan Kumar

Dr Rajendra Prasad Medical College,Kangra at Tanda

sudarshan_58@rediffmail.com9418086604

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026