Does Benzydamine hydrochloride oral rinses decrease pain and drug requirement after molar tooth extraction

Randomized controlled trial to compare oral analgesic requirements and patient satisfaction in using oral non-steroidal anti-inflammatory or benzydamine hydrochloride oral rinses after mandibular third molar extraction: A pilot study.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/08/009220

Enrollment

Registered

2017-08-01

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Third Molar pathology requiring extraction

Interventions

Intervention1: NSAID Vs Benzydamine hydrochloride: oral non-steroidal anti-inflammatory drugs or benzydamine hydrochloride oral rinses after mandibular third molar extraction Control Intervention1: Pa

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients 18years and above coming for fully erupted mandibular third molar extraction 2. Patients belonging to ASA physical statusI&II.

Exclusion criteria

Exclusion criteria: 1.Tooth requiring surgical extraction 2.Periodontally weak tooth 3.Tooth associated with peri-apical pathology 4.Tooth associated with fracture 5.Tooth with cellulitis or abscess 6.Tooth where adjacent 2nd molar can be a source of pain- eg. caries 7.Patients with other conditions that may alter the healing capacity post-extraction- like diabetes mellitus, those receiving bisphosphonate therapy or post radiotherapy patients 8.Patients with hypersensitivity to NSAIDS, peptic ulcer,GI bleed and myocardial infarction.

Design outcomes

Primary

Measure	Time frame
Scoring of pain in VAS. Trismus Total number of analgesics consumed Satisfaction level of the patient Timepoint: 3rd and 7th post operative day-	—

Secondary

Measure	Time frame
Pain, Trismus, Analgesic requirementTimepoint: 3rd to 7th Post operative day	—

Countries

India

Contacts

Public ContactDr Devalina Goswami

CDER, AIIMS, New Delhi

drdevalina@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026