Health Condition 1: null- Head Injury
Conditions
Interventions
Intervention1: Increasing cerebral perfusion pressure by 20%: Increasing cerebral perfusion pressure by 20% using noradrenaline
Intervention2: Increase in mean arterial pressure by 10%: In patients wh
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 20 adult patients of either gender, undergoing decompressive craniotomy following traumatic brain injury will be enrolled, over a period of 6 months
Exclusion criteria
Exclusion criteria: patients where microdialysis catheter cannot be placed or those with Glasgow coma score of 3 on admission, age less than 18 years, pregnant females and associated severe polytrauma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| â?¢ To see the effect of CPP augmentation on ischemia biomarkers (LP Ratio) and intracranial pressureTimepoint: Every one hour till 48 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| â?¢ To see the correlation between CPP, ICP, ischemia biomarkers on outcome in these patients. â?¢ To see the time interval between increase in ischemia biomarkers and clinical worsening (neurological status, rise in ICP) â?¢ To study the incidence of ischemia as measured by cerebral micodialysis (Lactate, pyruvate and LP ratio) in severe traumatic brain injury following decompressive craniectomy.Timepoint: Every hour till 48 hours | — |
Countries
India
Contacts
Public ContactDr Ashish Bindra
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed