Health Condition 1: null- Dementia (Alzheimers) Health Condition 2: G308- Other Alzheimers disease
Conditions
Interventions
Intervention1: Hapushadi Yapan Basti: HYB Dose- 380 ml
Dosage form- decoction
Route of administration- Anal
Time of administration- two hours after breakfast
Duration- 1 month
Parihaar Kala- 2 months
Intervention2: Brahmi Ghrita: BRAHMI GHRITA-Dose 40 gm twice daily
Route of Administration Oral
Duration of therapy- 3 months
Control Intervention1: Donepazil: Dose- 10mg daily, Dosage form- Tablet
Duration of therapy- 3 months
Sponsors
Department of Kayachikitsa
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients fulfilling the criteria of possible Alzheimerâ??s disease according to NINCDS- ADRDA 2.Patients without any other probable or possible causes of Dementia 3.Patients who has done at least primary education up to class five
Exclusion criteria
Exclusion criteria: 1. Patients with any kind of kidney disorders 2. Early onset of a focal seizure suggests 3. Previous or ongoing depression 4. Early prominent gait disturbance with only mild memory loss 5. Resting tremor with stooped posture 6. When dementia occurs after a well-established diagnosis of PD 7. The early appearance of Parkinsonian features in association with fluctuating alertness, visual hallucinations, or delusional misidentification suggests 8. Chronic alcoholism 9. Vitamin B12 deficiency 10. Chronic drug intoxication. 11. Dementia with any other explainable cause
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptomatic Improvement by Modified Mini Mental State (MMMS) testTimepoint: At Baseline, 30th day- 60th day and at the end of follow up on 90th day | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in Acetyl choline esterase level, Antioxidants, inflammatory markersTimepoint: At Baseline and on 90th day | — |
Countries
India
Contacts
Public ContactRICHA TRIPATHI
Institute of Medical Sciences, BHU
Outcome results
None listed