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A study to assess the effects of type 2 diabetes mellitus on cognition and depression

Assessment of cognition and depression in type 2 diabetic patients and their association with serum vitamin d, vitamin d binding protein and brain derived neurotrophic factor

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2017/07/009155
Enrollment
300
Registered
2017-07-28
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Type 2 Diabetes Mellitus

Interventions

Control Intervention1: NIL: NIL

Sponsors

Rizwana Parveen
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Cases 1. Men and women aged >=18 years and 2. Patients diagnosed with DM2 3. Willingness to give written informed consent Controls 1. Men and women aged >=18 years and 2. Healthy human subjects 3. Willingness to give written informed consent

Exclusion criteria

Exclusion criteria: Cases 1. Patients with Type 1 DM 2. Patients with a history of severe psychiatric disorders (eg; severe depression, schizophrenia, bipolar disorder) 3. Patients taking any substance of abuse (eg; alcohol, smoking) 4. Patients already on any psychotropic drug 5. Patients with severe complications of diabetes (i.e., amputation, blindness, renal insufficiency and dialysis) 6. Patients having liver disease, renal disease, primary hyperparathyroidism, cancer, HIV and obesity 7. Women who are pregnant or taking oral contraceptive pills 8. Patients taking vitamin D supplement 9. Unwillingness to give written informed consent Controls 1. Subjects taking vitamin D supplement 2. Unwillingness to give written informed consent

Design outcomes

Primary

MeasureTime frame
To assess the prevalence of probable cognitive impairment and depression in patients with type 2 diabetes mellitusTimepoint: 6 months—

Secondary

MeasureTime frame
1) To determine the cognitive function by using Mini Mental State Examination or Hindi Mini-Mental State Examination 2) To determine probable depression by using Patient Health Questionnaire-9 3) To assess the relation of serum vitamin D, serum vitamin D binding protein, serum brain derived neurotrophic factor levels with probable cognitive impairment and depression in patients with type 2 diabetes mellitusTimepoint: 1 Year—

Countries

India

Contacts

Public ContactRizwana Parveen

Jamia Hamdard

nidhiagarwal@jamiahamdard.ac.in9818334770

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026