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Comparison of two different methods of correcting vitamin b12 deficiencies

Comparison of two different regimens of vitamin B12 therapy in hematological manifestations of Macrocytic-Megaloblastic Anemia(nutritional) in children

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/07/009124
Enrollment
80
Registered
2017-07-27
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- MEGALOBLASTIC ANEMIA

Interventions

Intervention1: Oral Vitamin B12 tablets: 1000 ug Vitamin B12 will be given parenterally(IM/IV) on first occasion (within 24 hours of enrollment and consent) followed by oral supplementation of 500 ug

Sponsors

Utkarsh Pandya
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Suspected megaloblastic anemia in age group of 3 months to 18 years(Pallor, hyper-pigmentation of knuckles & terminal phalanges) clinically with one of the following laboratory criteria. a. Peripheral smear picture : macrocytes, hypersegmented neutrophils and thrombocytopenia b. MVC(Man corpuscular volume) > 110 fl c. Vitamin B12 level d. Dimorphic anemia on peripheral smear e. Infantile tremor syndrome (ITS)

Exclusion criteria

Exclusion criteria: 1. Patient with Neurological symptoms (except ITS) 2. Patient with proven or strongly suspected pernicious anemia or short boweL syndrome/malabsorption syndrome

Design outcomes

Primary

MeasureTime frame
IMPROVMENT IN HEMOGLOBIN ( ANEMIA CORRECTION OR 2 GM/DL) WITH VITAMIN B12 CORRECTION 400Timepoint: 3 months—

Secondary

MeasureTime frame
NOT APPLICABLETimepoint: NOT APPLICABLE—

Countries

India

Contacts

Public ContactDr Utkarsh Pandya

Pramukh Swami medical college

krutikart@charutarhealth.org9727352701

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026