Health Condition 1: null- patient under going surgery which requires general anasthesia
Conditions
Interventions
Intervention1: 3 µg/kg fentanyl during laryngoscopy and intubation in hypertensive population: 3 µg/kg fentanyl 5 minute before to laryngoscopy and intubation in hypertensive population to prevent
Sponsors
Department of Anaesthesiology Sir T Hospital Bhavnagar
Eligibility
Inclusion criteria
Inclusion criteria: NORMOTENSIVE PATIENT: 1 Age:20 to 50 years 2 Gender: Male and Female 3 ASA physical status I and II 4 Patient posted for elective surgery under general anaesthesia requiring endotracheal intubation 5 Surgery duration less than two hours 6 BMI 7 Informed written consent for participation in study. 8 Modified Mallampatti Classification I and II HYPERTENSIVE PATIENT: 1 Age:20 to 50 years 2 Gender: Male and Female 3 ASA physical status II(well controlled primary Idiopathic hypertension (blood pressure medications excluding β blocker) No end organ involvement due to hypertension. 4 Patient posted for elective surgery under general anaesthesia requiring endotracheal intubation 5 Surgery duration less than two hours 6 BMI 7 Informed written consent for participation in study. 8 Modified Mallampatti Classification I and II
Exclusion criteria
Exclusion criteria: 1 Patient refusing consent 2 Patient with Diabetes ,COPD, Renal disease, Cardiac diseases like IHD, Valvular heart disease, AV conduction block, LVF & Psychiatric illness etc. 3 Patient on drugs likes sedatives, opioids, anti-psychiatrics and β blockers. 4 ASA physical status III and above. 5 Anticipated difficult intubation. 6 BMI 25>=kg/m2 7 Intubation attempt lasting more than 20seconds 8 Patient on more than 3 antihypertensive medications. 9 Defaulter of taking antihypertensive medication as per schedule
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the efficacy and safety of fentanyl in attenuating hemodynamic stress response to laryngoscopy and endotracheal intubation in normotensive v/s controlled hypertensive patients in respect to following parameters: 1. Heart Rate (HR) 2. Systolic Blood Pressure (SBP) 3. Diastolic Blood Pressure (DBP) 4. Mean Arterial Pressure (MAP) 5. Change in cardiac rhythmTimepoint: base line-15 minute after premedication-5 minute after fentanyl-during laryngoscopy and intubation-after intubation(1,3,5,10,15,20,30,45,60,90,120 minute)-at the time of extubation-after extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| -To assess the sedative effect of fentanyl. -To observe complication if any in both groups. Timepoint: base line-15 minute after premedication-5 minute after fentanyl-during laryngoscopy and intubation-after intubation(1,3,5,10,15,20,30,45,60,90,120 minute)-at the time of extubation-after extubation | — |
Countries
India
Contacts
Public ContactDr DC Tripathi
Govt. Medical College, Bhavnagar.
Outcome results
None listed