Health Condition 1: null- Adult end stage chronic kidney disease patients undergoing renal transplant surgery
Conditions
Interventions
Intervention1: ropivacaine plus clonidine in TAP block: The skin of the patients on the side of operation was prepared from subcostal to inguinal region and area above iliac crest with 2.5% chlorhexid
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients undergoing renal transplantation.
Exclusion criteria
Exclusion criteria: 1.Refusal to participate 2.Infection at site of proposed block 3.Hypersensitivity to ropivacaine, clonidine or opioids 4.Inability to understand the functioning and use of Patient Controlled Analgesia (PCA)pump or Visual analogue scale
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post-operative 24 hour intravenous morphine consumptionTimepoint: 0 hour,2 hours, 6 hours, 12 hours, 24 hours in post- operative period | — |
Secondary
| Measure | Time frame |
|---|---|
| Intra-operative total intravenous fentanyl consumptionTimepoint: End of surgery;Number of boluses of intravenous morphine as rescue analgesia in 24 hour post-operative periodTimepoint: 0 hour,2 hours, 6 hours, 12 hours, 24 hours in post-operative period;Post-operative 24 hour pain scores on visual analogue scale (VAS 0-100)Timepoint: 0 hour,2 hours, 6 hours, 12 hours, 24 hours in the post-operative period;Side effects in the post operative period such as hypotension (blood pressure less than 25% of baseline), significant bradycardia (heart rate less than 50 beats/minute associated with hypotension),sedation (score more than 3 in Ramsay sedation scale), respiratory depression (respiratory rate less than 8 breath/minute or SpO2 less than 90% with oxygen by face mask), pruritus, post operative nausea and vomitingTimepoint: 0 hour, 2 hours, 6 hours, 12 hours, 24 hours in the post-operative period;Time to first analgesic use in the post operative periodTimepoint: Time point at which first analgesic was required in the post-operative period | — |
Countries
India
Contacts
Public ContactMahesh Kumar Arora
All India Institute of Medical Sciences, New delhi
Outcome results
None listed