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prophylactic administration of intravenous ondansetron after spinal anesthesia for prevention of fall in blood pressure and heart rate

Prophylactic Intravenous ondansetron for prevention of hypotension during spinal anesthesia for inguinal hernia repair: a prospective randomized clinical study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/07/009098
Enrollment
100
Registered
2017-07-21
Start date
Unknown
Completion date
Unknown
Last updated
2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- patients having inguinal hernia posted for surgical repair under spinal anesthesia

Interventions

Intervention1: Injection ondansetron: Inj. ondansetron 8mg Intravenous single dose ( total volume made into 5ml) given 20 minutes prior to performing spinal anesthesia Control Intervention1: normal sa

Sponsors

Indira Gandhi Institute of Medical Sciences Patna
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: patient aged between 20 - 50 yrs with weight 50-70 kgs Patient posted for hernia repair surgery under spinal anesthesia ASA physical status I & 2 Patients informed consent for participation in study

Exclusion criteria

Exclusion criteria: 1) Patient refusal. 2) Patients on opioid therapy/analgesics 3) Organ dysfunction, cardiac arrhythmia or congenital heart disease, and mental retardation. 4) Patients with history of drug allergy to study drugs 5) Patients with known contra-indications to spinal anesthesia. 6) Patient with co-morbidities such as hypertension, diabetes etc.

Design outcomes

Primary

MeasureTime frame
Incidence of hypotension after spinal anesthesia in patients with prophylactic intravenous ondansetronTimepoint: Blood pressure will be monitored at every minute interval for first 20 minute and then at 5 minute interval intra-operatively

Secondary

MeasureTime frame
Incidence of bradycardia in patients having inguinal hernia repair under spinal anesthesia with prophylactic ondansetronTimepoint: Heart rate at 1 minute interval for first 20 minutes , then at 5 minute interval intra-operatively

Countries

India

Contacts

Public ContactDr Saurav Shekhar

Indira Gandhi Institute of Medical Sciences

sauravshekhar99@gmail.com9308921568

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026