Health Condition 1: null- Primary Osteoarthritis Knee
Conditions
Interventions
Intervention1: Intraarticular administration of
tranexamic acid: 1.5g of TXA in 10 ml of normal
saline injected into the joint
through 18 gauge needle after
wound closure before tourniquet
release
Con
Sponsors
SUNSHINE HOSPITALS
Eligibility
Inclusion criteria
Inclusion criteria: 1. All patients undergoing total knee arthroplasty for primary arthroplasty knee 2.Patients who are willing to participate in the study. 3.Patient without exclusion criteria.
Exclusion criteria
Exclusion criteria: 1.Allergy to the TXA 2.H/O Coagulopathy,abnormal PT or APTT 3.Past H/O Thromboembolic event 4.Treatment with Aspirin or NSAIDS in the last week 5.plasma creatinine > 115 micro moles /litre for males And >100 micro moles/litre in females. 6.Acute infection[eg;leukocytosis or fever] 7.Malignancy 8.MI in preceding 12 months,unstable angina 9.Patient who were given plasma in perioperative period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Hemoglobin dropTimepoint: Assessed at 3 days of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Perioperative blood loss, need for post operative blood transfusion, impairment of renal function, occurrence of deep vein thrombosisTimepoint: 6 weeks | — |
Countries
India
Contacts
Public ContactDr Jefferson George
Sunshine Hospitals, Secunderabad
Outcome results
None listed