Health Condition 1: null- Parkinsons Disease Health Condition 2: G20- Parkinsons disease
Conditions
Sponsors
All India Institute Of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of clinically definite PD, defined by UKPD brain bank clinical and diagnostic criteria. With presence of at least 1 out of 3 cardinal motor features of PD (resting tremor, rigidity, and postural impairment like bradykinesia); 2. PD patients of both gender with H&Y stage from 1 to 3. 3. PD patients between age 45 to 85 on stable medication for at least 30 days.
Exclusion criteria
Exclusion criteria: Subjects with any other neurological, psychiatric co-morbidities were excluded from the study. Hypertensives and diabetics were included only if they were stable on antihypertensives and oral hypoglycaemics for past 6 months from the time of enrollment. Also subjects with any ferromagnetic implants or dental fillings were excluded so were the subjects who were eligible for deep brain stimulation (DBS) and were scheduled to undergo surgery in next 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| i. To compare the status of cortical plasticity between all the three treatment groups (M1, PM, SMA) using fMRI and FDG-PET. ii. To compare the clinical condition of the patients in the three treatment groups on the basis of UPDRS, H & Y scale, PDQ-39, HAM-A, HAM-D, HADS and CGI. iii. To compare the motor performance of the patient using Purdue peg-board test, and Timed motor tests. Timepoint: Baseline 0 day Post Sham at 4th week Post Real at 8th week [Baseline:-After recruitment Post-Sham:-After 4 sessions of Sham TMS Post-Real:- After 4 sessions of Real TMS.] | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.To compare the clinical condition of the patients in the three treatment groups on the basis of UPDRS, H & Y scale, PDQ-39, HAM-A, HAM-D, and CGI. 2.To compare the motor performance of the patient using Purdue peg-board test, and Timed motor tests. Timepoint: Baseline 0 day Post Sham at 4th week Post Real at 8th week [Baseline:-After recruitment Post-Sham:-After 4 sessions of Sham TMS Post-Real:- After 4 sessions of Real TMS.] | — |
Countries
India
Contacts
Public ContactPriyanka Bhat
Dept. Of Neurology, AIIMS, Delhi
Outcome results
None listed