Disinfection achieved during root canal treatment by 2 disinfecting agents -bromelain (pineapple stem extract), and sodium hypochlorite (the current treatment standard).

â??Comparison of anti-microbial efficacy of Bromelain extract and Sodium hypochlorite used as root canal irrigant in primary root canal treatment: a Randomized Controlled Clinical trialâ??.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/07/009015

Enrollment

Registered

2017-07-11

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Infected root canals (irreversible pulpitis or necrotic pulp with apical periodontitis)

Interventions

Intervention1: Bromelain: Non-toxic proteolytic agent, already in use in medicine for treatment of burn wounds -- to remove necrotic tissue, whilst preserving healthy vital tissue. Has properties favo

Eligibility

Inclusion criteria

Inclusion criteria: Maxillary or mandibular, incisors or canines; Endodontic diagnosis of irreversible pulpitis/ necrotic pulp, with apical periodontitis.

Exclusion criteria

Exclusion criteria: Previous endodontic treatment; Post-endodontic restoration not feasible; Intentional RCT; Vital pulp requiring RCT due to contraindication of vital pulp therapy.

Design outcomes

Primary

Measure	Time frame
Microbial analysis (change in Colony forming units).Timepoint: 1. Pre-operative microbial sampling; 2. Post-disinfection microbial sampling. There is no follow-up.	—

Secondary

Measure	Time frame
nilTimepoint: nil	—

Countries

India

Contacts

Public ContactSherin Jose Chockattu

Bapuji Dental College & Hospital

sherinjose.com@gmail.com9535542942

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026