Health Condition 1: null- Critically ill cirrhotics Health Condition 2: K746- Other and unspecified cirrhosis ofliver
Conditions
Interventions
Intervention1: High Target Mean Arterial Pressure: High target group (80-85 mm of Hg)
Control Intervention1: Low target MAP group (60-65mm Hg): Low target MAP group (60-65mm Hg).
Sponsors
Institute of liver and Biliary Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Critically ill cirrhotics with septic shock
Exclusion criteria
Exclusion criteria: 1) Patients with age less than 18 years 2) Severe known cardiopulmonary disease (structural or valvular heart disease, coronary artery disease, COPD) 3) Pregnancy 4) Chronic kidney disease on hemodialysis 5) Extremely moribund patients with an expected life expectancy of less than 24 hours 6) Failure to give informed consent from family members. 7) Hemodynamic instability requiring very high dose of vasopressors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SurvivalTimepoint: 28 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of ICU/Hospital stayTimepoint: 3 months;Duration of mechanical ventilationTimepoint: 3 months;Incidence of intradialytic hypotension in patients undergoing Renal Replacement TherapyTimepoint: 3 months;Reversal of Acute Kidney InjuryTimepoint: Day 5;Reversal of shockTimepoint: Day 5 | — |
Countries
India
Contacts
Public ContactDr Rakhi Maiwall
Institute of liver and Biliary Sciences
Outcome results
None listed