Is leucoreduced red cell transfusion have advantage over non-leucoreduced red cell transfusion in patients of pediatric cardiac surgery?

To assess the effect of leucoreduced red cell transfusions on inflammatory mediators and postoperative complications in pediatric cardiac surgery: double-blind, randomized controlled study.

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/07/008972

Enrollment

Registered

2017-07-04

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Ventricular Septal defect and tetrology of fellot patients undergoing cardiac surgery

Interventions

Intervention1: Buffy coat depleted SAGM suspended PRBC (S-PRBC): Buffy coat layer is reduced in these RBC and there is 1 log leucoreduction Intervention2: Pre-storage leukoreduced PRBC using 3rd gener

Eligibility

Inclusion criteria

Inclusion criteria: patients (upto 10 years of age) undergoing cardiac surgery for congenital heart disease, who had not received blood transfusion within the last 3 months.

Exclusion criteria

Exclusion criteria: Patients who have received blood transfusion in last three months and patients with Rh (D) negative blood group.

Design outcomes

Primary

Measure	Time frame
MortalityTimepoint: 90 days	—

Secondary

Measure	Time frame
In Hospital MortalityTimepoint: 30 days;Intensive care unit stayTimepoint: --;Post-op development of Multiple organ dysfunction syndromeTimepoint: 30 days;Post-operative infectionsTimepoint: 30 days;Total hospital stayTimepoint: --	—

Countries

India

Contacts

Public ContactHari Krishan Dhawan

Postgraduate Institute of Medical Education and Research

hkdpgimer@gmail.com9781112608

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026