Health Condition 1: null- patients undergoing surgery which require general anaesthesia
Conditions
Interventions
Intervention1: 0.3 mg/kg of nalbuphine
: 0.3 mg/kg of nalbuphine diluted up to 10 ml,
intravenously 10 minutes before induction
Control Intervention1: 3 µg/kg of fentanyl: 3 µg/kg of fentanyl dilu
Sponsors
Department of Anaesthesiology
Eligibility
Inclusion criteria
Inclusion criteria: Informed written consent for participation in study Age: 20 to 60 years. Either gender ASA physical status I and II. Patients posted for elective surgery for 2 hour duration, under general anaesthesia, requiring endotracheal intubation.
Exclusion criteria
Exclusion criteria: Patient refusal to participate in study. Hypersensitivity to drug. Patients with anticipated difficult airway. Patient with cardiac, pulmonary, neurologic, kidney diseases. Patients on drugs like sedatives, opioids and anti-psychiatric drugs. Intubation attempt lasting longer than 20 seconds.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the efficacy and safety of nalbuphine and fentanyl in attenuating haemodynamic stress response to laryngoscopy and endotracheal intubation. Timepoint: base line,study drug injection,2min,5min,10min,during laryngoscopy and intubation,1min,3min,5min,10min,15min,20min,30min,45min,60min,90min,120min,after extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the sedative effect of nalbuphine and fentanyl To observe complication if any, in two groups.Timepoint: base line,study drug injection,2min,5min,10min,during laryngoscopy and intubation,1min,3min,5min,10min,15min,20min,30min,45min,60min,90min,120min,after extubation | — |
Countries
India
Contacts
Public ContactDr Komal Shah
Govt Medical College Bhavnagar
Outcome results
None listed