Comparison of effect of two drugs (phenylephrine and norepinephrine) administered to maintain blood pressure in pregnant patients undergoing caesarean section under spinal anaesthesia on the mother and the newborn

A comparison of efficacy of prophylactic infusion of Phenylephrine versus Norepinephrine for the prevention of post spinal hypotension in parturients undergoing elective caesarean section- A randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/06/008915

Enrollment

130

Registered

2017-06-27

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- WOMEN UNDERGOING ELECTIVE CAESAREAN SECTION

Interventions

Intervention1: NOREPINEPHRINE: INFUSION 5mcg/min at 2.5 ml/min (i.e. 2mcg/ml). Control Intervention1: PHENYLEPHRINE: INFUSION 25mcg/min at 2.5ml/min (i.e. 10mcg/ml)

Eligibility

Inclusion criteria

Inclusion criteria: 1. WOMEN OF SINGLETON PREGNANCY WITH GESTATIONAL AGE OF MORE THAN 36 WEEKS OF GESTATION 2. ASA I AND II WOMEN

Exclusion criteria

Exclusion criteria: 1. Patient refusal 2. Multiple gestation 3. Pregnancy with severe systemic illness (uncontrolled diabetes, hypertension, cardiac disease, etc.) 4. BMI > 40 kg/m2 5. In active labour 6. Suspected obstetric complications ( like polyhydraminos, IUGR) 7. Patients in whom spinal anaesthesia is contraindicated (spinal abnormalities, infection at the site of injection, coagulopathies, raised intracranial tension)

Design outcomes

Primary

Measure	Time frame
To compare the incidence and severity of hypotension, following prophylactic infusion of phenylephrine and norepinephrine in parturients undergoing LSCS under spinal anaesthesiaTimepoint: In the period between administration of spinal anaesthesia and upto the skin closure	—

Secondary

Measure	Time frame
Occurrence of maternal bradycardia, reactive hypertension, total rescue vasopressor requirement, neonatal acid-base status and APGAR scoresTimepoint: during the surgery and immediate postpartum period	—

Countries

India

Contacts

Public ContactBANUPRIYA

ALL INDIA INSTITUTE OF MEDICAL SCIENCES

drsrajeshwari@gmail.com9677629587

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026