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To Analyze the Effect of Bone healing in Periapical Defects using Simvastatin, Hydroxyappatite and PRF as bone grafts by clinicaly and radiographicaly.

Effect of Local Application of Simvastatin in Bone Regeneration of Peri-Apical Defects- A Clinicoradiographic Studyâ??

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/06/008881
Enrollment
33
Registered
2017-06-20
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- chronic apical periodontitis

Interventions

Intervention1: peri-apical surgery: 1- PRF 2- simvastatin with gelspon as a carrier Control Intervention1: peri-apical surgery: hydroxyappatite bone graft material

Sponsors

Dr Sweety Gupta
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1- patients with chronic periapical pathology 2- Aged 18 â?? 40 yrs 3- Mandibular and maxillary anterior teeth

Exclusion criteria

Exclusion criteria: 1- Previous history of periapical surgery 2- Smokers and other abusive habits 3- Systemically compromised patients 4- Patients on statins 5- Patients not willing for treatment

Design outcomes

Primary

MeasureTime frame
The primary outcome will be bony healing of the periapical area which will be evaluated after 3, 6 and 12 months postoperatively with CBCT Timepoint: 6 months and 12 months postoperatively with CBCT—

Secondary

MeasureTime frame
swelling, pain, pus discharge or presence of sinus will be evaluated after 1 week clinically post operativelyTimepoint: 1 week postoperatively—

Countries

India

Contacts

Public ContactDr Rhythm

KGMU

promilarajesh@yahoo.co.in9415542063

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026