Health Condition 1: E039- Hypothyroidism, unspecified Health Condition 2: null- Patients with hypothyroidism and requiring a more than ususal (1.7 mcg/kg/day) thyroxine with poor control. (TSH mor than 10mcIu/ml)
Conditions
Interventions
Intervention1: Once weekly thyroxine -Dose 450 to 1300 mcg per week for 12 weeks: Directly observed hospital administered once weekly 1.7X Body Wt X 7 mcg/ week treatment for 6 weeks. Then domicilary
Sponsors
State board of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: 1) Patients with TSH >10 mcIU/ml inspite of a Thyroxine dose more than 1.7 mcg/kg/day. 2)Those requiring a thyroxine dose more than 3mcg/kg body weight/day.
Exclusion criteria
Exclusion criteria: 1) Patients with critical Illness 2) Patients unwilling for the study. 3) Patients with known gastrointestinal malabsorptivedisrorders. 4)Patients with known structural, ischemic or rhythm disease of the heart. 5) Patients on medications known to decrease thyroxine absorption or hasten metabolism. 6) Patients accepting non-compliance to medications missing even one dose in last 6 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decrease in TSH from baseline.Timepoint: 6 weeks and 12 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of patients achieving TSH less than 5 mcIU/mlTimepoint: 6 weeks, 12 weeks | — |
Countries
India
Contacts
Public ContactAbilash Nair
Govt. Medical College Thiruvananthapuram
Outcome results
None listed