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A Clinical Trial to Compare the Effect of Dexmedetomidine and Propofol Infusion for Sedation during Awake Brain Surgery

A Comparison of the Effectiveness of Dexmedetomidine versus Propofol Infusion for Sedation during Awake Craniotomy - DPAC Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/06/008852
Enrollment
40
Registered
2017-06-16
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA 1and 2 and3

Interventions

Intervention1: dexmedetomidine: Loading dose of 1 microgm/kg Dexmedetomidine will be given as intravenous infusion over 10 minutes after echocardiography, pulse oximetry , end tidal carbon-di-oxide, r

Sponsors

AIIMS NEW DELHI
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: all awake consenting patients undergoing awake craniotomy

Exclusion criteria

Exclusion criteria: are uncooperative, with diminished levels of consciousness, mental retardation, with anticipated difficult intubation, obstructive sleep apnoea, medical conditions preventing to lie down for many hours, severe bradycardia, any type of atrioventricular block on the ECG, heart failure, and allergy to the study drugs will be excluded from the study

Design outcomes

Primary

MeasureTime frame
To study the respiratory complications (Hypoventilation, Hypoxia, Hypercarbia, Desaturation SpO2 90%, Airway obstruction) between the two groups Timepoint: intraoperative period

Secondary

MeasureTime frame
haemodynamic disturbances, pain, nausea/vomiting, brain bulge, seizures, duration of postoperative analgesiaTimepoint: Intraoperatively at: 1.Baseline 2.10 minutes after starting infusion 3.During scalp block 4.During pin fixation 5.During skin incision 6.During bone flap elevation 7. During dural incision 8. Dt tumor excision 9. At dural closure 10.At skin closure Postoperatively when patient will complain pain first time with VAS Score more then 4 after surgery

Countries

India

Contacts

Public ContactGirija Prasad Rath

AIIMS, New Delhi

drsokhal@yahoo.co.in9968713296

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026