Health Condition 1: null- Children with Acute Symptomatic Seizure in Children with Acute Encephalitis syndrome
Conditions
Interventions
Intervention1: 4 weeks arm: One of the group of children shall be randomized to tapering of anti-convulsant medication after 4 weeks of illness
Control Intervention1: 12 weeks arm: The second group of
Sponsors
Post Graduate Institute of Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: Children with acute encephalitis syndrome with acute symptomatic seizures on single anti-epileptic drug will be enrolled in Out patient clinic at 4 week of illness
Exclusion criteria
Exclusion criteria: 1.Children with chronic meningitis, brain abscess, intracranial Space occupying lesion 2.Children with prior history of seizures, prior focal neurological deficit or abnormal development prior to development of seizures 3.HIV, Chronic Liver disease, Chronic Kidney disease, acute hepatic encephalopathy 4.Children on two or more than 2 anti-epileptic drug, severely affected children (Pediatric Cerebral Performance Category Scale (PCPC) Score, Pediatric Overall Performance Category Scale with category score of 5) 5.Refusal of consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Seizure relapse rate (proportion) after stopping anti-epileptic drugs in children with acute symptomatic seizure in the two treatment groups after 6-months of follow upTimepoint: 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Correlation of EEG findings at time of stoppage of AED with seizure recurrence 2.Factors associated with seizure recurrence in the two groupsTimepoint: 6 months;Seizure relapse rate (proportion) after stopping anti-epileptic drugs after 12, 18 and 24-months of follow upTimepoint: 12-months, 18 months and 24 months | — |
Countries
India
Contacts
Public ContactDhawan Sumeet Rajendra
Post Graduate Institute of Medical Education and Research, Chandigarh
Outcome results
None listed