Comparison of two fluids meant for intravenous use(normal saline and plasmalyte) in patients who are undergoing surgery on an elective basis for brain tumours

Comparison of Normal Saline and Plasmalyte in Patients Undergoing Elective Craniotomy for Supratentorial Brain Tumours

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/06/008771

Enrollment

Registered

2017-06-06

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients aged 18 to 60 years undergoing elective craniotomy for Supratentorial tumours. They should belong to ASA class 1/2/3.

Interventions

Intervention1: Plasmalyte (ringer acetate): Plasmalyte is an intravenous fluid which is iso osmolar to plasma. Its osmolality is 294 moms/l. Normal saline causes hyperchloremic metabolic acidosis wher

Eligibility

Inclusion criteria

Inclusion criteria: Patients belonging to ASA class 1/2/3 posted for elective craniotomy for Supratentorial brain tumours

Exclusion criteria

Exclusion criteria: Patients with pre existing renal failure( serum creatinine >2) patients with electrolyte disturbances Patients having received previous mannitol therapy

Design outcomes

Primary

Measure	Time frame
Arterial blood gas analysis primarily to measure pH and chloride levelsTimepoint: 0,2,4,6 hours after commencement of surgery	—

Secondary

Measure	Time frame
Plasma osmolality between the two groupsTimepoint: At 0,3,6,9 hours	—

Countries

India

Contacts

Public ContactAnkita Dey

JIPMER

adinarayanans@gmail.com9442396762

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026