Health Condition 1: null- Lichen planus pigmentosus
Conditions
Interventions
Intervention1: Nd-YAG laser: 6 sittings will be done on a lesion present at the covered body site, at 2 weekly interval
Control Intervention1: Nil: Nil
Sponsors
Intramural Project All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients presenting with slate-gray hyperpigmented macules over neck, trunk or extremities 2. Histological evaluation showing minimal inflammatory infiltrate with presence of dermal pigment
Exclusion criteria
Exclusion criteria: 1. The presence of dense inflammatory infiltrate in dermis 2. Age less than 18 years 3. Patients not able to follow-up frequently 4. Patients with active infections, keloidal tendency, clotting abnormalities and serious systemic diseases 5. Pregnant or lactating females
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical improvement in pigmentation in patients with lichen planus pigmentosus with 6 sessions of Q switched Nd-YAG laser for 3 months at 2-weeks interval. Timepoint: Patient and physician assessment of improvement as well as objective measurement of reduction in melanin pigment will be done at each visit and after 2 weeks of last laser visit | — |
Secondary
| Measure | Time frame |
|---|---|
| Detailed evaluation of the effect of laser on the dermal melanin pigment and melanophages in these patients. This will be done by comparing the pre and post treatment immunohistochemistry and mRNA expression analysis of MART-1, tyrosinase, MITF, CD68 and CD163.Timepoint: In five patients, post-treatment analysis done immediately one hour after the first laser session will help in determining the immediate effect of the laser on the destruction of melanophages and melanin. In the remaining five patients, this analysis done 2 weeks after the last laser visit will help in evaluation of long term effect of the laser on these cells. | — |
Countries
India
Contacts
Public ContactDr Neetu Bhari
All India Institute of Medical Science, New Delhi
Outcome results
None listed