Health Condition 1: null- Periodontal Disease
Conditions
Interventions
None listed
Sponsors
Dr Ashish Jain
Dr Vishakha Grover
Eligibility
Inclusion criteria
Inclusion criteria: Periodontal diagnosis will be based on the periodontal classification of the American Academy of Periodontology (1999) and American Academy of Periodontology Task Force Report on the Update to the 1999 Classification of Periodontal Diseases and Conditions (2015). Each subject will be included in any of the following four groups depending upon his/her clinical condition and treatment requirements as: a) Group (1) (Control): 11 age matched patients showing clinically healthy gingiva without bleeding and no evidence of bone resorption or periodontal pockets. b) Group (2) (Gingivitis) : 11 patients presenting with clinical evidence of gingivitis, such as red color, swelling of the gingival margin and bleeding corresponding to gingival indices 2 and 3 (Löe and Silness) without bone resorption or periodontal pocketing. c) Group (3) (Moderate Periodontitis): 11 patients with 3â??4mm CAL, 5â??7mm pockets, 16% to 30% or >3 mm & d) Group (4) (Severe Periodontitis): 11 patients with >=5mm CAL, >=7mm pockets, >30% or >5 mm radiographic bone loss with presence of bleeding on probing.
Exclusion criteria
Exclusion criteria: Patients with the history of: 1. Pregnancy, lactation, smoking 2. Any systemic condition that could affect the progression of periodontal disease (e.g., diabetes and immunological disorders) 3. Long-term administration of anti-inflammatory medication 4. Excessive consumption of alcohol 5. Localized radiation therapy of the oral cavity 6. On any medications or have undergone periodontal therapy within the preceding 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.To determine the total macrophages using CD68 by immunohistochemical (IHC) analysis in groups. 2.To determine the count for M1 and M2 by IHC analysis in groups. 3.To determine the relative ratio of M1 and M2 and its correlation to periodontal health and disease. 4.To evaluate histologically the severity of inflammation and correlate it with the relative ratio of M1 and M2. 5.To correlate the clinical parameters of periodontal health and disease with the relative ratio of M1 and M2.Timepoint: One point | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Clinical Parameters based on various indices 2. Histological evaluation of severity of inflammationTimepoint: One point | — |
Countries
India
Contacts
Public ContactGurjeet Kaur
Dr Harvansh Singh Judge Institute of Dental Sciences and Hospital Panjab University CHANDIGARH
Outcome results
None listed