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A novel way to reduce complications in patients with cerebral aneurysm

Effect of remote ischemic preconditioning on cerebral vasospasm and biomarkers of cerebral ischemia in patients with cerebral aneurysmal sub arachnoid hemorrhage: a randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/06/008724
Enrollment
24
Registered
2017-06-01
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Cerebral aneurysmal sub arachnoid haemorrhage Health Condition 2: G988- Other disorders of nervous system

Interventions

Intervention1: True remote ischemic preconditioning: The RIPC protocol will include three 5min cycles of upper limb ischemia with 5 minute intervals of reperfusion in between. The blood pressure cuff

Sponsors

NIMHANS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Anterior cerebral circulation aneurysm with sub arachnoid haemorrhage 2.WFNS grade 1 and 2 3.Presentation within 3 days of ictus 4.Scheduled to undergo surgical clipping of aneurysm

Exclusion criteria

Exclusion criteria: 1.Patients with upper limb cellulitis or ulcers or peripheral vascular disease 2.Posterior circulation aneurysm 3.WFNS grade 3 or more 4.Presentation beyond 3 days of ictus 5.No consent from the patient or patient attenders 6.Interventional or conservative management of aneurysm 7.Unruptured aneurysm

Design outcomes

Primary

MeasureTime frame
1.Vasospasm as assessed on TCD (Transcranial Doppler) and or cerebral angiogram Clinical signs of vasospasm will also be noted but confirmation for this study will be based on either TCD or angiographic evidence. 2.Serum biomarkers- Area under the curve concentration of S100B and NSE(Neuron Specific Enolase) levels. Timepoint: 1.TCD will be done every 24 hours until 7-10 days post ictus or until discharge, whichever is earlier. Cerebral angiography parameters done at the time of diagnosis and subsequently any time thereafter during the hospital stay will be recorded. 2.Serum biomarkers- Baseline at the time of recruitment (pre- first RIPC) At 24-36 hours after the first session of RIPC Repeated at day 7-10 after ictus or at discharge whichever is earlier.—

Secondary

MeasureTime frame
1.Neurological status - The Glasgow coma scale (GCS) and GOSE (Glasgow outcome scale-extended) score 2.Regional cerebral oxygenationTimepoint: GCS and regional cerebral oxygenation using NIRS- every 24 hours during the period of stay in the hospital. GOSE at discharge and at 1, 3 and 6 months through a telephonic interview.—

Countries

India

Contacts

Public ContactDr Ramesh VJ

National Institute of Mental Health and Neurosciences

drvjramesh@gmail.com9844432607

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026