Health Condition 1: null- Mild to moderate alcoholic hepatitis
Conditions
Interventions
Intervention1: Phyllanthus niruri: Capsule Phyllanthus niruri 500 mg BD for 4 weeks
Control Intervention1: Placebo: Similar looking placebo capsule 500 mg BD for 4 weeks
Sponsors
JIPMER Intramural fund
Eligibility
Inclusion criteria
Inclusion criteria: Alcoholic hepatitis patients aged 18-65 years with present history of alcohol abuse of either gender as confirmed by CAGE questionnaire score >=2 Patients with abnormal liver function tests with AST/ALT ratio >2
Exclusion criteria
Exclusion criteria: Patients who are terminally ill (encephalopathy, spontaneous bacterial peritonitis, hepatorenal syndrome) with severe alcoholic hepatitis (Maddreys discriminant function >=32) Patients with viral and drug induced hepatitis Patients with comorbid conditions like coronary artery disease, peripheral vascular disease etc. Pregnant women or lactating mothers; Women in reproductive age group not practicing contraceptive measures Patients who had participated in other trials in the past three months Patients on herbal medications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AST, ALT, ALP, bilirubin, albumin, prothrombin time, creatinine, blood urea nitrogen, complete hemogramTimepoint: Baseline, at the end of 2 weeks and 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Oxidative stress markers (serum malondialdehyde) and anti-oxidant enzymes (reduced glutathione, total oxidant status and total antioxidant status), symptoms and adverse drug reactionsTimepoint: Baeline, at the end of 2 weeks and 4 weeks | — |
Countries
India
Contacts
Public ContactDr Chanaveerappa Bammigatti
JIPMER
Outcome results
None listed