Effect of pulpal medicine on periodontal healing

Effect of 2% Chlorhexidene when used alone and in sequence with a Triple antibiotic paste as intracanal medicament on endodontal - periodontal lesions - A double blinded randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/05/008660

Enrollment

Registered

2017-05-25

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Pulpo periodontal lesions

Interventions

Intervention1: Intracanal medicaments Test arm A:Triple antibiotic paste(Ciprofloxacin,Metronidazole,Minocycline)followed by 2% Chlorhexidene gel Test arm B:2% Chlorhexidene gel : Intracanal medica

Eligibility

Inclusion criteria

Inclusion criteria: 1. Clinical and radiographic diagnosis of a combined endodontic periodontal lesion 2. Probing pocket depth [PPD] >= 6 mm 3. Wide base pocket 4. Pulpal necrosis as confirmed by negative response to cold and electric pulp test 5. Radiographic alveolar bone destruction without apical communication

Exclusion criteria

Exclusion criteria: 1. Younger than 18 years 2. Pregnant, diabetic, or immunocomprimised 3. Smokers and tobacco chewers 4. Grade 3 mobile teeth 5. Unrestorable tooth 6. Patients with aggressive periodontitis 7. History of recent periodontal therapy within the previous 6 months

Design outcomes

Primary

Measure	Time frame
1. Probing pocket depth 2. Clinical attachment level 3. Bleeding on probing Timepoint: Time Frame 6 months	—

Secondary

Measure	Time frame
Subjective assessment of pain (Dichotomized as yes or no) will be assessed at baseline and during monthly visits. Further assessment of clinical signs of progression of disease like development of abscess, mobility etc will also be assessed.Timepoint: Time Frame : 6 months	—

Countries

India

Contacts

Public ContactShanmuga Priya

Sri Venkateshwara Dental College

drshanpriya@gmail.com9003286399

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026