Comparison of Lignocaine and Dexmedetomidine to prevent presser response during routine tracheostomy tube change in traumatic brain injury patients

To compare the effect of dexmedetomidine and lignocaine on the attenuation of airway and pressor response during tracheostomy tube change in traumatic brain injury patients in trauma ICU

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/05/008570

Enrollment

100

Registered

2017-05-16

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Tracheostomized head injury patient in trauma ICU, both male and female patients undergoing tracheostomy tube change according to ICU protocol.

Interventions

Intervention1: Inj. Dexmedetomidine hydro-chloride: Inj. Dexmedetomidine hydro-chloride 0.5 mcg/kg IV (Inj. Dexem 100mcg/ml, Themis Medicare)infusion over 10 minute after diluted in 100 ml normal sali

Eligibility

Inclusion criteria

Inclusion criteria: 1.Tracheostomized Traumatic brain injury patients in ICU. 2.Patients with intact cough reflex. 3.Spontaneously breathing patients on T-piece or on room air.

Exclusion criteria

Exclusion criteria: 1.Cervical spine injury. 2.HR below 60/min. 3.Arterial pressure less than 100/60 mmHg. 4.History of allergic reactions to study drugs. 5.Refusal to take part in the study 6.Patients with COPD /Asthma /Diabetes/ Hypertension. 7.Patients on Neuromuscular blockers or any sedative drugs. 8. Patient on ventilator.

Design outcomes

Primary

Measure	Time frame
Hemodynamics and cough reflexTimepoint: 60 minutes	—

Secondary

Measure	Time frame
Any adverse eventTimepoint: 60 minutes	—

Countries

India

Contacts

Public ContactDr Yashpal Singh

Institute of Medical Sciences, Banaras Hindu University, Varanasi

dryashacin1999@rediffmail.com919918424416

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026