Health Condition 1: null- Sepsis Health Condition 2: A419- Sepsis, unspecified organism
Conditions
Interventions
Intervention1: PCT group: In this group antibiotic therapy will be stopped based on serial PCT measurements starting from admission. PCT levels will be obtained at admission and every 3rd day thereaft
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Children 2 month to 17 years admitted to the ICU and already receiving antibiotics for suspected or proven sepsis -defined as systemic inflammatory response syndrome or SIRS due to infection, and 2. children who are started on antibiotics in the ICU for suspected or proven sepsis
Exclusion criteria
Exclusion criteria: 1. Children receiving antibiotics more than 24 hours before presentation, 2. Those with severe immunosuppression (CD4 count of less than 200 cells/mm3 neutropenic patients ( 3. Estimated length of stay less than 24 hrs, 4. Underlying co-morbidities with possible imminent death, 5. Severely malnourished children and 6. Children whose parents refuse to give an informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion with treatment failure during the course of ICU stayTimepoint: Measured from 48 hours after stopping antibiotics till discharge or death | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Proportion of children who are clinically cured (defined as resolution of signs and symptoms for which antibiotics were started). 2. Proportion developing septic shock or ARDS during the course. 3. Duration of antibiotic therapy in overall population and as per type/ source/ site infection Timepoint: 1. Measured after first antibiotic course from the time of admission 2. Measured from the time of stopping the antibiotic therapy 3. Total duration of antibiotic therapy during the ICU stay including the first course | — |
Countries
India
Contacts
Public ContactJhuma Sankar
All India Institute of Medical Sciences
Outcome results
None listed