Health Condition 1: null- patients with traumatic brain injury (TBI), defined by a Glasgow coma scale (GCS) score of less than 15 admitted to the hospital.
Conditions
Interventions
Intervention1: Group A: gold nanoparticles based UCHL1 assay Levels
Control Intervention1: Group B: fluorescence-based UCHL1 assay levels in serum of brain trauma patients.
Sponsors
JPNA TRAUMA CENTRE AIIMS
Eligibility
Inclusion criteria
Inclusion criteria: All admitted brain trauma patients with GCS less than 15 with or without extracranial injuries.
Exclusion criteria
Exclusion criteria: Patients with recent or old stroke history, patients with Alzheimer or Parkinsonâ??s disease and patients with associated various malignancies including leukemia (ALL), breast cancer, medullary thyroid carcinoma, non-small cell lung carcinoma, neuroblastoma, and in prostate, esophageal, colorectal and pancreatic cancer etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To validate the results of new technique (gold nanoparticles based UCHL1 assay) with other standard modalities (i.e. Glasgow coma scale and CT scan) to diagnosis and determine severity of brain trauma.Timepoint: at the time of admission and discharge from hospital | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To compare the results of new technique (gold nanoparticles based UCHL1 assay) with presently available (fluorescence-based UCHL1 assay) in terms of sensitivity and specificity. 2. To correlate the level of UCHL1 in blood (serum) sample with the outcome at discharge (disability and death) in patients of brain trauma. Timepoint: at the time of admission and discharge from hospital | — |
Countries
India
Contacts
Public ContactDr Gaurav Singh Tomar
All India Institute of Medical Sciences
Outcome results
None listed