Health Condition 1: null- Primary osteoarthritis knee
Conditions
Interventions
Intervention1: Intraarticualr administration of tranexamic acid: 1.5g of TXA in 10 ml of normal saline injected into the joint through 18 gauge needle after wound closure before tourniquet release
Con
Sponsors
Sri Sathya Sai Institute of Higher Medical Sciences Prasanthigram
Eligibility
Inclusion criteria
Inclusion criteria: 1. All patients undergoing total knee arthroplasty for primary arthroplasty knee 2.Patients who are willing to participate in the study. 3.Patient without exclusion criteria.
Exclusion criteria
Exclusion criteria: 1.Allergy to the TXA 2.H/O Coagulopathy,abnormal PT or APTT 3.Past H/O Thromboembolic event 4.Treatment with Aspirin or NSAIDS in the last week 5.plasma creatinine > 115 micro moles /litre for males And >100 micro moles/litre in females. 6.Acute infection[eg;leukocytosis or fever] 7.Malignancy 8.MI in preceding 12 months,unstable angina 9.Patient who were given plasma in perioperative period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Hemoglobon dropTimepoint: Assessed at 5 days of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Perioperative blood loss, need for post operative blood transfusion, impairment of renal function, occurrence of deep vein thrombosisTimepoint: 6 weeks | — |
Countries
India
Contacts
Public ContactDr Tulaja Prasad P V
Sri Sathya Sai Institute of Higher Medical Sciences - Prasanthigram
Outcome results
None listed