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Whether transiently increasing breath volume and measuring variability in blood pressure and variability in size of major blood vessel in abdomen in pts receiving low breath volume from breathing machine who has poor lung functions would help in predicting the response to fluid therapy?

To determine whether Tidal volume challenge can improve the reliability of pulse pressure variation and stroke volume variation in patients having low respiratory system compliance and also that of inferior vena cava distensibility index in predicting fluid responsiveness in patients ventilated using low tidal volume

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/04/008378
Enrollment
26
Registered
2017-04-20
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Pt with Acute circulatory failure and Receiving protective lung ventilation less than or equal to 6ml/kg using Volume control mode without any spontaneous activity and with cardiac output monitoring

Interventions

Intervention1: Tidal volume challange: Transiently increasing Tidal volume from 6 ml per kg to 8 ml per kg for one minute duration and recording set of parameters. Control Intervention1: There is no c

Sponsors

Dept of Anaesthesia Critical care and Pain
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Adult patients (Age > 18 yrs ) 2.Acute circulatory failure 3.Receiving protective lung ventilation 4.With cardiac output monitoring using Flotrac/Volume View with Phillips Intel View monitor (MP700) 5.Treating physician has decided to give fluid bolus

Exclusion criteria

Exclusion criteria: 1.Cardiac arrhythmias, Acute myocardial infarction 2.Previously known significant valvular disease or intracardiac shunt 3.Air leakage through chest drains 4.Right heart failure 5.An urgently required fluid challenge 6.Abdominal compartment syndrome, and pregnancy

Design outcomes

Primary

MeasureTime frame
To determine whether the â??tidal volume challengeâ?? can improve the reliability of PPV and SVV in predicting fluid responsiveness in patients having low lung compliance ventilated using low Vt ventilationTimepoint: before and after giving fluid therapy—

Secondary

MeasureTime frame
1.To determine whether IVC-DI can reliably predict fluid responsiveness in patients receiving low Vt ventilation 2.To determine whether the â??tidal volume challengeâ?? can improve the reliability of IVC-DI in predicting fluid responsiveness in patients receiving low Vt ventilation Timepoint: before and after giving fluid therapy—

Countries

India

Contacts

Public ContactDr Natesh Prabu

Tata Memorial Hospital

nateshchillsout@yahoo.com9969523803

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026