Health Condition 1: null- Epilepsy
Conditions
Interventions
Intervention1: Donepezil: 10 mg tablets in the morning.
Oral for 6 months
Intervention2: Zolpidem (sustained release): 6.25 mg tablets at bedtime.
Oral for six months
Control Intervention1: Placebo: O
Sponsors
Department of Health and Research
Eligibility
Inclusion criteria
Inclusion criteria: 1. Consequent patients diagnosed as TLE, FLE and JME by a single investigator (the PI), based on clinical, EEG, video-EEG and neuroimaging features, will be recruited as cases.
Exclusion criteria
Exclusion criteria: 1. if they have any additional epilepsy syndrome or if they cannot be classified into any of these categories; 2.if there is an established diagnosis of primary sleep disorders; 3.if there is a past history of prolonged status epilepticus which was followed by abrupt deterioration in sensorium and/or cognitive performance; 4.history of major traumatic brain injury, encephalitis or other neurological disorder with encephalopathy, after onset of epilepsy 5.if they suffer from cardiac arrhythmias or bronchial asthma or impaired renal or liver functions. 6.if they have severe mental subnormality (IQ
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive performance. Quality of life.Timepoint: 6 Months | — |
Secondary
| Measure | Time frame |
|---|---|
| REM sleep percentage Slow wave sleep percentage. 50% or greater reduction in Seizure frequency Quality of sleep (Sleep efficiency) Change in daytime sleepiness (Epworth sleepiness scale) Timepoint: 6 Months | — |
Countries
India
Contacts
Public ContactDr Garima Shukla
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed