Health Condition 1: null- Vitamin D deficient hypothyroid patients
Conditions
Interventions
Intervention1: Vitamin D: Tablet vitamin D 60,000 IU one tablet once weekly for 8 weeks in addition to standard background therapy(Tablet Levothyroxine)
Control Intervention1: Placebo: Matching placeb
Sponsors
JIPMER intramural
Eligibility
Inclusion criteria
Inclusion criteria: i. Newly diagnosed hypothyroid patients with TSH >10mIU/L ii. Vitamin D deficiency
Exclusion criteria
Exclusion criteria: i.Liver dysfunction (AST,ALT > 2 times the upper limit of normal) ii.Renal dysfunction (GFR iii.Patient with concurrent illnesses like Diabetes mellitus, Hypertension, CAD (Coronary Artery Disease), CVA(cerebrovascular accidents), PVD (Peripheral Vascular Disease), CKD (Chronic Kidney Disease), renal calculi, thyroid and other malignancy, those on concurrent treatment for tuberculosis, bariatric surgery procedure or malabsorption disorders and any clinical indication for vitamin D treatment. iv.Pregnant women or lactating mothers. v.Patients who had participated in other trials in the past three months. vi.Smokers vii.Alcoholics viii.Patients taking medication like glucocorticoids, anti-retroviral agents, orlistat
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Carotid femoral pulse wave velocityTimepoint: Baseline, before starting vitamin D and 8 weeks after starting vitamin D | — |
Secondary
| Measure | Time frame |
|---|---|
| hsCRP, IL-6, IL-10 and TNF-αTimepoint: Before starting vitamin D or placebo, 8 wks after starting vitamin D or placebo | — |
Countries
India
Contacts
Public ContactDr Sadishkumar Kamalanathan
JIPMER, Puducherry
Outcome results
None listed