Health Condition 1: null- Depression
Conditions
Interventions
Intervention1: L-Methylfolate,Escitalopram: Antidepressant
Escitalopram: 10-20mg once daily oral dosage
L-Methylfolate: 7.5-15mg once daily oral dosage
Total duration of therapy: 8 weeks
Control Inter
Sponsors
Director Principal Government medical college and hospital Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: 1) Patients with primary diagnosis of moderate to severe depression according to ICD-10 DCR criteria. These patients should be treatment naïve or if receiving treatment should have regular compliance to it for at least 6 weeks and not be responding to the current treatment as defined by response of 2) Patients having HAM-D score of >=17, at time of intake which indicates at least moderate degree of depression. 3) Patient and his/her relative willing to give informed consent.
Exclusion criteria
Exclusion criteria: 1) Breastfeeding, and pregnant females 2) Having a current serious suicide risk, or psychotic symptoms 3) Unstable medical illness requiring concomitant use of other medication including those medications which are known to have depressogenic effect ( corticosteroids, anti-epileptics, beta-blockers, quinolone class of antibiotics, interferons, anti-neoplastic drugs). 4) Having an active substance use disorder within the past 6 months (in terms of fulfilling criteria for substance-harmful use or substance dependence) except nicotine and caffeine use. 5) Having past history of mania/hypomania (including antidepressant-induced), psychotic symptoms, or seizure disorder. 6) Taking vitamins or dietary supplements containing folate or vitamin B12. 7) Having comorbid diagnosis of intellectual disability, dementia, Alzheimerâ??s disease, or Parkinsonâ??s disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in HAM-D scoreTimepoint: 0,2,4,6,8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in quality of life and functioningTimepoint: 0,4,8 weeks | — |
Countries
India
Contacts
Public ContactSushmita Bhattacharya
Government medical college and hospital, sector 32, Chandigarh
Outcome results
None listed