Health Condition 1: null- Cancer of Uterine Cervix
Conditions
Interventions
Intervention1: Single application multi-fractionated high dose rate brachytherapy in cervical cancer: Patient will receive external beam radiotherapy and if suitable concurrent chemotherapy as per sta
Sponsors
Tata Memorial Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1) Histologically diagnosed invasive cervical cancer (squamous carcinoma, adenosquamous carcinoma, adenocarcinoma) 2) FIGO stage II B - IV A after thorough clinical examination and work-up investigation. 3) Suitable for radical radiation therapy with/without chemotherapy, and also for brachytherapy boost. 4)Accepts the Informed consent process and signs the form on his/her will.
Exclusion criteria
Exclusion criteria: 1)Patients with vesico-vaginal fistula or recto-vaginal fistula at diagnosis. 2)Patients at high risk of anaesthesia and patients with phobia /contra-indications to undergo MRI. 3)Patients not suitable for brachytherapy. 4)Metastatic disease beyond iliac on standard imaging. 5)Vault cancers/recurrence. 6)Previous history of pelvic radiation. 7)Non-compliance to treatment. 8)Medical or psychological illness precluding treatment protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) To evaluate feasibility to achieve dosimetric constraints for target and organs at risk, thus safety to deliver multi-fractionated brachytherapy in a single applicationTimepoint: 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) To evaluate inter fraction dose variation for organs at risk Timepoint: 1 year;To assess clinical outcomes in terms of late Gastrointestinal (GI)/Genitourinary (GU)/vaginal toxicities (grade 3 or more) and local control rates. Timepoint: 2 years | — |
Countries
India
Contacts
Public ContactDr Umesh Mahantshetty
Tata Memorial Hospital
Outcome results
None listed