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The effect of dexamethasone on blood glucose concentrations in diabetic and non diabetic surgical patients

A PROSPECTIVE STUDY ON THE IMPACT OF LOW DOSE DEXAMETHASONE ON PERIOPERATIVE BLOOD GLUCOSE CONCENTRATIONS IN DIABETICS AND NON DIABETICS

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/03/008150
Enrollment
180
Registered
2017-03-20
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients with and without Diabetes mellitus posted for elective surgery

Interventions

Intervention1: A single dose of 4mg or Dexamethasone 8 mg diluted to 5ml with normal saline before administration of spinal anaesthesia: 1. Reduction in PONV 2. Record any changes in Blood glucose The

Sponsors

M S Ramaiah Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Age between 18-70 years 2 American Society of Anaesthesiologists (ASA) Grade I or II. 3 Patients with weight >=50kg 4 Patients undergoing lower extremities and infra umbilical surgeries under spinal anaesthesia. 5 Pre operative GRBS between 80 - 180 mg %

Exclusion criteria

Exclusion criteria: 1.Recent IV or oral steroid therapy within last 48 hours 2.Allergy to dexamethasone 3. Conversion to General anaesthesia 4.Body mass index >35

Design outcomes

Primary

MeasureTime frame
The outcome of the study is to observe blood glucose concentrations after placebo and 4 or 8mg of dexamethasone in non-diabetic and type 2 diabetic patients undergoing routine surgery under spinal anaesthesia.Timepoint: Finger prick capillary blood glucose will be measured immediately before dexamethasone administration (T0) and at 60 minutes (T1), 120 minutes (T2), 180 minutes (T3), 240 minutes (T4), 360 minutes (T5) and 480 minutes(T6) thereafter using a glucometer—

Secondary

MeasureTime frame
Incidence of postoperative nausea and vomiting following Dexamethasone 4mg/8mg compared to placeboTimepoint: Finger prick capillary blood glucose will be measured immediately before dexamethasone administration (T0) and at 60 (T1), 120 (T2), 180 (T3), 240 (T4), 360 (T5) and 480 minutes(T6) thereafter using a glucometer.—

Countries

India

Contacts

Public ContactDr ATHUL M PURUSHOTHAMAN

M S RAMAIAH MEDICAL COLLEGE

drvinayak@yahoo.com9900859460

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026