A clinical trial to compare the effect of two drugs, dexmedetomidine and esmolol as blood pressure controlling agents in patients undergoing ENT surgeries.

A comparative study to evaluate the efficacy of dexmedetomidine as a hypotensive agent in comparison to esmolol in ASA grade 1-2 patients undergoing ENT surgeries.

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/03/008077

Enrollment

Registered

2017-03-14

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA grade I-II patients of both sexes aged between 18-60 yrs, undergoing Otorhinolaryngeal (ENT) surgeries.

Interventions

Intervention1: INJ. ESMOLOL: Patients in E group (assigned to receive esmolol) patients will receive esmolol as a loading dose (1 mg/kg) infused over 1 min followed by continuous infusion of (0.4-0.8

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18- 60 yrs of both the sexes, undergoing planned Otorhinolaryngeal (ENT) surgeries with ASA grade I-II.

Exclusion criteria

Exclusion criteria: 1.Patients refusing to give informed consent. 2.Patients with recurrent sinus surgery and patients with systemic co-morbidities like hypertension, coronory artery disease, renal or hepatic disease, cerebro vascular accidents. 3.Patients with coagulopathies or receiving drugs which have effects on coagulation profile.

Design outcomes

Primary

Measure	Time frame
primary outcome is to compare the quality of the surgical field using a predefined category scaleTimepoint: surgical field score	—

Secondary

Measure	Time frame
compare the efficacy and safety of dexmedetomidine with Esmolol as a hypotensive agent in ENT surgeries with attention on analgesia requirement, recovery profile, and tolerability in adult patients.Timepoint: sedation score, visual analogue score, modified aldrete score	—

Countries

India

Contacts

Public ContactDr Shilpa Bansal

Adesh university

Shilpa_shinde24@rediffmail.com09915433522

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026