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Prevention of nausea and vomiting in middle ear surgery by Comparison of palonosetron & dexamethasone and ondansetron & dexamethasone combination

Comparison of efficacy of palonosetron & dexamethasone and ondansetron & dexamethasone combination for prevention of postoperative nausea and vomiting in patients undergoing middle ear surgery- A randomized double blind study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/03/007998
Enrollment
60
Registered
2017-03-03
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA grade I and II, Non hypertensive and non diabetic

Interventions

Intervention1: Ondansetron & Dexamethasone: Ondansetron 8 mg and dexamethasone 8 mg intravenously prior to induction of anesthesia Control Intervention1: Palonosetron & dexamethasone: Palonosetron 0.0

Sponsors

Apollo Hospitals Bilaspur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA grade I and II 2. Non hypertensive and non diabetic

Exclusion criteria

Exclusion criteria: 1.Known allergy to study drug 2.Use of antiemetic drugs 24 hours before surgery. 3.Morbid obesity (body mass index >40) 4.Chronic use of opioids 5.Diabetes and hypertension 6.Hepatic, renal or cardiovascular dysfunction 7.Psychiatric patients 8.Pregnant and lactating women

Design outcomes

Primary

MeasureTime frame
Incidence and severity of nausea and vomitingTimepoint: During postoperative period 0–2 hr, 2–6 hr and 6–24 h after surgery

Secondary

MeasureTime frame
Patients satisfaction score Requirement of rescue antiemeticTimepoint: Satisfaction score 24 hr after surgery Rescue antiemetic during 0-2 hr, 2-6 hr and 6-24 hr

Countries

India

Contacts

Public ContactDr Vinit Kumar Srivastava

Apollo Hospitals Bilaspur

ahmadshakeel817@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026