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A study on comparison between esmolol bolus and infusion in blunting the increase in heart rate and blood pressure following intubation

Comparison of esmolol bolus with esmolol infusion in reducing peri intubation stress response in non cardiac surgical patients: A randomized controlled trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/03/007994
Enrollment
126
Registered
2017-03-02
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA 1 AND 2 patients posted for elective sugery in the age group 18-70

Interventions

Intervention1: Esmolol bolus: Esmolol bolus- 1.5mg/kg, given over 30 seconds 3 minutes prior to intubation. Control Intervention1: esmolol: after giving loading dose of 0.5mg/kg followed by infusion o

Sponsors

Christian Medical College Vellore
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA 1 and ASA 2 patients 2. Patients posted only for elective non cardiac surgery 3. patients accepting to give informed written consent

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Heart rate less than 60 per minute 3. Systolic blood pressure less than 100mm Hg 4. Hepatic failure 5. Renal failure 6. Cardiac conduction abnormalities 7. Patients on beta blockers 8. History of asthma or chronic obstructive pulmonary disease 9. History of intolerance to beta blockers 10. Obesity (body mass index more than 30) 11. Total duration of laryngoscopy more than 30 seconds 12. Patients who are unable to understand and give consent for participation. 13. Patients less than 18 and more than 70 years old. 14. Patients who are part of other studies. 15. Difficult airway. 16. ASA PS III and IV.

Design outcomes

Primary

MeasureTime frame
1. Blood pressure 2. Heart rateTimepoint: 1. Baseline 2. preintubation 1st minute 3. Preintubation 2nd minute 4. postintubation - every minute for 5 minutes—

Secondary

MeasureTime frame
side effects such as rash, vomiting, seizuresTimepoint: 1. Baseline 2. preintubation 1st minute 3. Preintubation 2nd minute 4. postintubation - every minute for 5 minutes—

Countries

India

Contacts

Public ContactDr Sathish Kumar Dharmalingam

Christian Medical College, Vellore

annsumintoms@yahoo.com8098018088

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026