Health Condition 1: null- Mild to moderate chronic periodontitis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1) 20- 60 year old males and females 2) With mild to moderate periodontitis - This selection is based according to American Academy of Periodontology (1999) : the classification of severity is as follows: mild : 1-2 mm of clinical attachment loss moderate : 3-4 mm of clinical attachment loss severe : > 5 mm of clinical attachment loss 3) Presence of minimum of 20 teeth
Exclusion criteria
Exclusion criteria: 1) Patient with any systemic diseases, severe liver or kidney disease, or severely ill patients with multiple drug requirements, patients with iron deficiency, anemia, anxiety, bleeding disorders, heart conditions, history of peptic ulcers. 2) Patients consuming any concurrent medications or those who have taken antibiotics or antiinflammatory medication in the past 6 months, similar products or mouthwashes. 3) Patient with any orthodontic or prosthodontic appliance 4) Patient with oral abusive habits such as smoking, alcohol intake and betel nut chewing or any other form of tobacco 5) Pregnant or lactating mothers 6) Patients who have undergone any periodontal treatment in the last 6 months 7) Patients with a high polyphenol diet (green tea, fish)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Glutathione peroxidase levels in saliva, gingival crevicular fluid and serum 2. Malondialdehyde levels in saliva, gingival crevicular fluid and serum 3. Total antioxidant levels in saliva, gingival crevicular fluid and serum Timepoint: Baseline 1 month after start of study 3 months after start of study | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Gingival index- Loe and Silness (1963) 2. Plaque Index- Silness and Loe (1964) 3. Probing pocket depth 4. Clinical attachment loss 5. % of sites with bleeding on probing. 6. Lobene stain index 7.The estimation of Colony Forming Units (C.F.U) will be done for selective supragingival plaque bacteria such as S. aureus, S. mutans, P. gingivalis, P. intermedia, F. nucleatum, S. salivarius and S. sanguisTimepoint: Baseline 1 month after start of study 3 months after start of study | — |
Countries
India
Contacts
Manipal College of Dental Sciences, Manipal