Health Condition 1: null- Alopecia areata
Conditions
Interventions
Intervention1: Autologous platelet-rich plasma: Patients will be treated with 2ml of autologous platelet-rich plasma injected intra-dermally every month for 3 months on one side of the scalp.
Control
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Adult (age > 18 years) patients with alopecia areata of the scalp of duration atleast 6 months with symmetrically distributed patches of hair loss on the scalp
Exclusion criteria
Exclusion criteria: 1. Patients with alopecia areata with asymmetrically distributed patches of hair loss on scalp 2. Patients with a co-existent scalp or hair disorder 3. Patients with thrombocytopenia ( 4. Patients with underlying systemic illness, including autoimmune disorders 5. Pregnant or lactating female patients 6. Patients not consenting to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Severity of alopecia tool score at visits 1, 2, 3 and 4 2. Percentage of dystrophic hair on dermoscopic photomicrograph at visits 1, 2, 3 and 4 3. Patient global assessment at visits 2, 3 and 4 4. mRNA expression profile of Th1, Th2, Th17 and T-regulatory cell specific-markers in the lesional skin at visits 1 and 4 Timepoint: Visits 1, 2, 3 and 4. Every visit is at one monthly interval. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quantitative levels of Th1, Th2, Th17 and T-regulatory cell specific-markers in the lesional skin by immunohistochemistry at visits 1 and 4Timepoint: Visits 1 and 4 | — |
Countries
India
Contacts
Public ContactDr Vinod Kumar Sharma
All India Institute of Medical Sciences
Outcome results
None listed