Health Condition 1: null- singleton pregnancy with pre-eclampsia, requiring cesarean delivery under subarachnoid block
Conditions
Interventions
Intervention1: nil: nil
Control Intervention1: Nil: Nil
Sponsors
PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: This study will be conducted in a total of 80 pre-eclamptic parturients, with singleton pregnancy, taken up for non elective cesarean delivery under spinal anaesthesia
Exclusion criteria
Exclusion criteria: - Any contraindication to spinal anaesthesia - Gestation below 32 weeks - Local or generalized sepsis - Twin pregnancy - Presence of hyperuricemia before pregnancy - Pre existing heart disease, liver or renal disorders - Pre existing or gestational diabetes mellitus and chronic hypertension - Pre-eclampsia parturients who are on therapeutic doses of magnesium sulphate for severe features - Patient refusal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.The incidence of post-spinal hypotension (fall of more than 20% of MAP from baseline values) in pre-eclamptic parturients with raised serum uric acid levels.Timepoint: non-invasive blood pressure (NIBP) will be taken at 1-min interval till the birth of the baby and then every 5 minutes | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Total amount of vasopressor administered to maintain targeted MAP 2. Episodes of hypotension 3. Adverse effects like intraoperative nausea / vomiting 4. Short term neonatal outcome 5. maternal blood loss Timepoint: 1. Total amount of vasopressor- before delivery of the baby 2. Episodes of hypotension following administration of spinal anesthesia upto the time of uterine incision. 3. Adverse effects like intraoperative nausea / vomiting - throughout the perioperative period 4. Short term neonatal outcome: 1 and 5 minute Apgar score, 5. maternal blood loss - intraoperative period | — |
Countries
India
Contacts
Public ContactDr Nidhi Bhatia
PGIMER, Chandigarh
Outcome results
None listed