None listed
Conditions
Interventions
None listed
Sponsors
Bill and Melinda Gates Foundation
Eligibility
Inclusion criteria
Inclusion criteria: 1. Controls and cases will be of both genders, aged 18 - 24 months, all consuming an adequate daily intake of energy and protein and not being breast-fed. 2. Controls will have good health, normal weight and height and normal gut function. 3. Cases will be otherwise healthy except for presence of EED and possibly stunting (HAZ
Exclusion criteria
Exclusion criteria: 1. For all children will be presence of chronic infection(s) or a pre-existing medical condition 2. Recent history ( 3. Antibiotic usage in the last 4 weeks of study recruitment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tryptophan Flux, oxidation, and bioavailability for body protein synthesis, and niacin synthesis, Enrichment of Trp in VLDL-apoB-100, Concentrations of Amino Acids, Trp, Kynurenine ( K:T ratio), Albumin, Prealbumin, Fibrinogen, CRP and niacin concentrations, IGF-1, Inflammatory cytokines INF-a, TNF-a, markers of gut function,fecal neopterin, myeloperoxidase, alpha-1 anti-trypsin, Reg1B and plasma EndoCAb, Total and Resting Energy Expenditures, body composition Timepoint: One time point | — |
Secondary
| Measure | Time frame |
|---|---|
| Determining rice, finger millet and whole egg digestibility using the same method proposed for mung bean Timepoint: One time point;Markers of gut function: fecal neopterin, myeloperoxidase, alpha-1 anti-trypsin, Reg1B and plasma EndoCAb, fecal microbial analysis Total Energy Expenditure (TEE) and body composition in the study participantsTimepoint: One time point | — |
Countries
India
Contacts
Public ContactAnura V Kurpad
St. Johns National Academy of Health Sciences
Outcome results
None listed