To compare the effect of two drugs for alleviating propofol injection pain.

Prevention of pain on injection of propofol:-A comparision of pre-treatment with Palonosetron and lignocaine.

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/02/007873

Enrollment

100

Registered

2017-02-15

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Physically fit as per ASA guidelines (1&2)

Interventions

Intervention1: Lignocaine: Pretreatment with 5ml lignocaine (40mg) will be followed by propofol injection. Pain assessment will be done immediately thereafter. Control Intervention1: Palonosetron: Pre

Eligibility

Inclusion criteria

Inclusion criteria: Patients of AAA physical status 1and 2 Patients between 18-60 years of age of either sex Patients able to comprehend and willing to participate Patients in whom propofol is indicated for Induction of anaesthetia

Exclusion criteria

Exclusion criteria: Patients refusal to participate Contraindications to use of palonosetron Patients with known sensitivity to lignocaine or propofol or palonosetron Patients on concomitant analgesic or sedative Patients with presence of infection on the dorsum of the left hand

Design outcomes

Primary

Measure	Time frame
Incidence and severity of pain on propofol injection.Timepoint: Immediately after injection.	—

Secondary

Measure	Time frame
Effect on haemodynamicsTimepoint: Immediately after injection	—

Countries

India

Contacts

Public ContactPRAKASH KUMAR DUBEY

INDIRA GANDHI INSTITUTE OF MEDICAL SCIENCES

pkdubey@hotmail.com09430511851

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026