Health Condition 1: null- Vitamin D deficient Chronic Urticaria
Conditions
Interventions
Intervention1: Tab Vitamin D Oral: 60,000 IU once in 2 weeks for 3 months through oral route.
Control Intervention1: Placebo Oral: Placebo once in 2 weeks for 3 months through oral route.
Sponsors
JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: Age and gender matched consenting patients with Chronic urticaria (presence of continuous or recurrent hives with or without angioedema for greater than 6 weeks duration) with vitamin D deficiency (serum vitamin D less than 20 ng per ml) attending the Dermatology Clinic in JIPMER during the study period
Exclusion criteria
Exclusion criteria: Patients with •Acute urticaria/physical urticaria/urticarial vasculitis •Hereditary or acquired angioedema •Symptoms of vitamin D deficiency such as musculoskeletal pain, fractures •Patients with hepatic or renal dysfunction •Malignancies/ Infections •Inflammatory cutaneous disorders (psoriasis, lichen planus, pityriasis rubra pilaris, erythroderma, allergic contact dermatitis) •Pregnant and lactating women will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study the effect of Vitamin D on clinical outcome by USS(Urticaria Severity Score)Timepoint: Baseline, 6 and 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the changes in levels of 25-hydroxy vitamin D, vitamin D binding protein, hs-CRP ,TGF-β, IL-17, IL-6.Timepoint: Baseline and 12 weeks | — |
Countries
India
Contacts
Public ContactMalathi M
JIPMER
Outcome results
None listed